The Bill & Melinda Gates Foundation Reinvent the Toilet (RT) program aims to “bring sustainable sanitation solutions to the 2.5 billion people worldwide who don’t have access.” Duke University and partners have developed a modular, on-site waste processing system that seeks to provide safe and reliable treatment of all inputs that exceed the metrics set by ISO 30500. Currently, sub-systems are being evaluated and re-engineered to reduce complexity, reduce energy reliance, and develop strategies for productization. To further the development of such transformative technologies, field prototypes have transitioned from the laboratory to field testing sites (Ahmedabad and Coimbatore, India and Durban, South Africa).